Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome.
Authors of this article are:
Alan M, Gurlek B, Yilmaz A, Aksit M, Aslanipour B, Gulhan İ, Mehmet C, Taner CE.
A summary of the article is shown below:
Asprosin associated with insulin resistance is a newly discovered peptide hormone. The peptide promotes hepatic glucose production. Polycystic ovary syndrome (PCOS) is a metabolic disorder. Insulin resistance plays a vital role in the pathogenesis of the disease. The aim of this study was to discover the association between insulin resistance and asprosin in women with PCOS. We recruited 78 subjects with PCOS and 78 age-matched and body mass index (BMI)-matched controls into this cross-sectional study. Circulating asprosin levels were validated using ELISA method. We also determined metabolic and hormonal parameters of the involved subjects. We found that circulating asprosin levels were elevated in women with PCOS with respect to controls. Asprosin levels showed a positive correlation with insulin resistance, BMI, and free androgen index (FAI). Moreover, subjects with the highest tertile of asprosin levels represented increased odds of having PCOS as compared to those subjects with the lowest tertile asprosin levels. Increased asprosin levels resulted to high possibility of having PCOS risk associated with insulin resistance.
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This article is a good source of information and a good way to become familiar with topics such as:
Polycystic ovary syndrome;asprosin;body mass index;insulin resistance
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