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Pain Susceptibility Phenotypes in Those Free of Knee Pain with or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study.

A new interesting article has been published in Arthritis Rheumatol. 2018 Oct 11. doi: 10.1002/art.40752. and titled:

Pain Susceptibility Phenotypes in Those Free of Knee Pain with or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study.

Authors of this article are:

Carlesso LC, Segal NA, Frey-Law L, Zhang Y, Lu N, Nevitt M, Lewis CE, Neogi T.

A summary of the article is shown below:

OBJECTIVES: Why some individuals develop pain with knee osteoarthritis (OA) is not clear. We sought to identify pain susceptibility phenotypes (PSPs) and their relation to incident persistent knee pain (PKP) 2 years later.METHODS: We identified individuals free of PKP from the Multicenter Osteoarthritis Study, a longitudinal cohort of older adults with or at risk of knee OA. Latent class analysis was used to determine PSPs that may contribute to development of PKP apart from structural pathology: widespread pain, poor sleep, psychological factors and quantitative sensory tests (QST) (i.e., pressure pain threshold and temporal summation (TS)). We evaluated the association of sociodemographic factors with PSPs and the relation of PSPs to developing PKP over two years with logistic regression.RESULTS: 852 participants were included (mean age 67; BMI 29.5 kg/m2 , 55% women). Four PSPs were identified, primarily characterized by varying proportions (low/absent, moderate, or high) of the presence of pressure pain sensitivity and of facilitated TS, reflecting different measures of sensitization. The PSP with high proportion of pressure pain sensitivity + moderate proportion of facilitated TS was twice as likely to develop incident PKP over 2 years OR 2.11 (95% CI 1.06 4.22) compared with the PSP having low proportion of sensitization by both measures.CONCLUSIONS: Four PSPs were identified, of which three were predominated by QST evidence of sensitization, and one was associated with developing PKP 2 years later. Prevention or amelioration of sensitization may be a novel approach to preventing onset of persistent knee pain in OA. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: knee osteoarthritis;latent class analysis;pain sensitization;phenotype.

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