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Use of dapagliflozin in patients with advanced diabetic kidney disease.

A new interesting article has been published in Kidney Res Clin Pract. 2018 Sep;37(3):292-297. doi: 10.23876/j.krcp.2018.37.3.292. Epub 2018 Sep 30. and titled:

Use of dapagliflozin in patients with advanced diabetic kidney disease.

Authors of this article are:
Park HS Jung YJ Lee DY Moon KH Kim B Kim HW.

A summary of the article is shown below:
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective for overweight diabetic patients through the induction of glucosuria. However, SGLT2 inhibitors are not recommended for patients with advanced chronic kidney disease (CKD) because they may aggravate renal function and thus become less effective in controlling blood glucose in this patient population. We suggest that adequate hydration would be helpful to prevent the side effects of SGLT2 inhibitors in diabetic patients with advanced CKD. In this study, we review five cases of SGLT2 inhibitor therapy, specifically with dapagliflozin, for the treatment of diabetes mellitus in patients with advanced CKD. The patients experienced dramatic weight reduction, improved glucose control, and further benefits without aggravation of renal function.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Albuminuria;Chronic kidney disease;Dapagliflozin;Hyperuricemia;Obesity.

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