Linear gadolinium-based contrast agent (gadodiamide and gadopentetate dimeglumine)-induced high signal intensity on unenhanced T1 -weighted images …
Authors of this article are:
Ichikawa S, Omiya Y, Onishi H, Motosugi U.
A summary of the article is shown below:
BACKGROUND: Recent studies of adults have found an association between hyperintensity of the dentate nucleus (DN) and globus pallidus (GP) on T1 -weighted images (T1 WI) and a history of linear gadolinium-based contrast agent (GBCA) administration. Several reports have also focused on this phenomenon in pediatric patients; however, data in the current literature remains limited.PURPOSE/HYPOTHESIS: To evaluate the associations between DN and GP T1 -signal increase and previous administration of linear GBCAs in pediatric patients.STUDY TYPE: Single-center, retrospective, cross-sectional study.POPULATION: We included pediatric patients with histories of ≥5 linear GBCA (gadodiamide and gadopentetate dimeglumine) administrations (the “≥5 Linear GBCA administrations” group), 1-4 administrations (the “1-4 Linear GBCA administrations” group), and no history of GBCA administration (the “No GBCA administration” group). Each group included 42 patients. Therefore, 126 patients (male:female, 72:54; median age, 16 [range, 4-18] years) were included in this study.FIELD STRENGTH/SEQUENCE: 1.5T/ Spin-echo unenhanced T1 -weighted imaging.ASSESSMENT: Unenhanced T1 -weighted images were quantitatively analyzed by two radiologists. The DN-to-pons and GP-to-thalamus signal intensity ratios (DN-to-pons and GP-to-thalamus ratios, respectively) were compared.STATISTICAL TESTS: Wilcoxon test with the Bonferroni correction and intraclass correlation coefficients.RESULTS: The DN-to-pons ratio increased as the number of GBCA administrations increased (P < 0.0063). The GP-to-thalamus ratio of the "≥5 Linear GBCA administrations" group was significantly higher than those of the other two groups (P < 0.0001). The GP-to-thalamus ratio of the "1-4 Linear GBCA administrations" group did not differ significantly from that of the "No GBCA administration" group (P = 1.000). The DN-to-pons and GP-to-thalamus ratios' interobserver intraclass correlation coefficients were excellent (0.8236) and good (0.6738), respectively.DATA CONCLUSION: High signal intensities in the DN and GP on T1 WI were associated with previous linear GBCA administration in pediatric patients.LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.© 2018 International Society for Magnetic Resonance in Medicine.
Check out the article’s website on Pubmed for more information:
This article is a good source of information and a good way to become familiar with topics such as: n/a.
Categories: Science News