TReNDS – software for reaction monitoring with time-resolved non-uniform sampling.
Authors of this article are:
Urbańczyk M Shchukina A Gołowicz D Kazimierczuk K.
A summary of the article is shown below:
NMR spectroscopy, used routinely for structure elucidation, has also become a widely applied tool for process and reaction monitoring. However, the most informative of NMR methods – correlation experiments – are often useless in this kind of applications. The traditional sampling of a multidimensional FID is usually time-consuming, and thus the reaction-monitoring toolbox was practically limited to 1D experiments (with rare exceptions, e.g. single-scan or fast-sampling experiments). Recently, the technique of time-resolved non-uniform sampling (TR-NUS) has been proposed, which allows to use standard multidimensional pulse sequences preserving the temporal resolution close to that achievable in 1D experiments. However, the method existed only as a prototype and did not allow on-the-fly processing during the reaction. In this paper, we introduce TReNDS: free, user-friendly software kit for acquisition and processing of TR-NUS data. The program works on Bruker, Agilent and Magritek spectrometers, allowing to carry out up to four experiments with interleaved TR-NUS. The performance of the program is demonstrated on the example of enzymatic hydrolysis of sucrose.
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This article is a good source of information and a good way to become familiar with topics such as: Time-Resolved N-Dimensional Spectroscopy;compressed sensing;non-uniform sampling;reaction monitoring.
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