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The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review.

A new interesting article has been published in Hormones (Athens). 2018 Sep 25. doi: 10.1007/s42000-018-0063-z. Review and titled:

The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review.

Authors of this article are:
Grammatiki M Karras S Kotsa K.

A summary of the article is shown below:
Diabetes mellitus, a metabolic disorder associated with chronic complications, is traditionally classified into two main subtypes. Type 1 diabetes mellitus (T1DM) results from gradual pancreatic islet β cell autoimmune destruction, extending over months or years. Type 2 diabetes mellitus (T2DM) is a heterogeneous disorder, with both insulin resistance and impairment in insulin secretion contributing to its pathogenesis. Vitamin D is a fat-soluble vitamin with an established role in calcium metabolism. Recently, several studies have provided evidence suggesting a role for it in various non-skeletal metabolic conditions, including both types of diabetes mellitus. Preclinical studies of vitamin D action on insulin secretion, insulin action, inflammatory processes, and immune regulation, along with evidence of an increase of hypovitaminosis D worldwide, have prompted several epidemiological, observational, and supplementation clinical studies investigating a potential biological interaction between hypovitaminosis D and diabetes. This narrative review aims to summarize current knowledge on the effect of vitamin D on T1DM and T2DM pathogenesis, prevention, and treatment, as well as on micro- and macrovascular complications of the disease. Furthermore, on the basis of current existing evidence, we aim to highlight areas for potential future research.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Cholecalciferol;Diabetes complications;Type 1 diabetes mellitus;Type 2 diabetes mellitus;Vitamin D.

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