Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas
Authors of this article are:
Widodo I Dwianingsih EK Utoro T Anwar SL Aryandono T Soeripto S.
A summary of the article is shown below:
BACKGROUND: Breast carcinomas (BCs) are sub-classified according to the molecular characteristics into luminal and non-luminal subtypes that clinically show different biological behavior, treatment and prognosis. BCs spread primarily through lymphatic vessels using cascade processes of lymphagiogenesis in which VEGF-C plays an important role during lymph node metastasis. Prognostic value of VEGF-C in luminal and non-luminal BC is still unclear and has not been studied thoroughly to clarify and define prognosis and therapeutic monitoring.AIM: To define the prognostic value of lymphangiogenesis on survival rates of luminal and non-luminal subtypes BC.MATERIALS AND METHODS: This study applied prospective cohort design, using 130 patients of invasive duct carcinoma of the breast, stage I-IIIA, from Sardjito General Hospital, Indonesia and subsequent longitudinal follow-up. Immunohistochemical staining was carried out using anti-ER, -PR, -Her-2, VEGF-C, VEGFR-3 and D2-40 antibodies. The related clinicopathologic characteristics of BC patients and lymphangiogenesis determinants, including VEGF-C expression, were statistically analyzed.RESULTS: In non-luminal BC subtypes, VEGF-C expression (HR=0.04; 95% CI=0.01-0.41), lymph node metastasis (HR=0.14; 95% CI=0.04-0.55) and stage (HR=0.30; 95% CI= 0.02-0.76) were determined as independent prognostic factors on survival rates. However, the lymphangiogenesis determinants were not associated with the survival rates of luminal BC subtypes.CONCLUSION: This study suggested that lymphangiogenesis affects survival rates of non-Luminal subtype rather than the luminal subtypes of BC.
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This article is a good source of information and a good way to become familiar with topics such as: Breast carcinoma;luminal and non-luminal subtype;lymphangiogenesis;VEGF-C;survival.
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