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Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics.

A new interesting article has been published in J Control Release. 2018 Oct 10;287:247-256. doi: 10.1016/j.jconrel.2018.08.027. Epub 2018 Aug 29. and titled:

Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics.

Authors of this article are:
Cerea M1, Maroni A1, Palugan L1, Bellini M2, Foppoli A3, Melocchi A1, Zema L1, Gazzaniga A1.

A summary of the article is shown below:
A decrease in the release rate over time is typically encountered when dealing with hydrophilic matrix systems for oral prolonged release due to progressive increase of the distance the drug molecules have to cover to diffuse outwards and reduction of the area of the glassy matrix at the swelling front. In order to solve this issue, a novel formulation approach based on non-uniform distribution of the active ingredient throughout the swellable polymer matrix was proposed and evaluated. Various physical mixtures of polymer (high-viscosity hypromellose) and drug tracer (acetaminophen), having decreasing concentrations of the latter, were applied by powder-layering onto inert core seeds. The resulting gradient matrices showed to possess satisfactory physico-technological characteristics, with spherical shape and consistent thickness of the layers sequentially applied. The non-uniform matrix composition pursued was confirmed by Raman mapping analysis. As compared with a system having uniform distribution of the drug tracer, the multi-layer formulations were proved to enhance linearity of release. The simple design concept, advantageous technique, which involves no solvents nor high-impact drying operations, and the polymeric material of established use make the delivery platform hereby proposed a valuable strategy to improve the performance of hydrophilic matrix systems.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: Gradient concentration;Hydrophilic matrices;Oral prolonged release;Powder layering;Tangential spray rotary fluid bed;Zero-order kinetics.

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