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Iron-catalysed carbene-transfer reactions of diazo acetonitrile.

A new interesting article has been published in Org Biomol Chem. 2018 Oct 10;16(39):7129-7133. doi: 10.1039/c8ob01991f. and titled:

Iron-catalysed carbene-transfer reactions of diazo acetonitrile.

Authors of this article are:
Empel C Hock KJ Koenigs RM.

A summary of the article is shown below:
A continuous-flow protocol for the synthesis of diazo acetonitrile was developed. It was further applied in iron-catalysed insertion reactions of diazo acetonitrile into N-H and S-H bonds to yield valuable α-substituted acetonitrile, including gram-scale synthesis.

Check out the article’s website on Pubmed for more information:



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