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Impaired IL-12- and IL-23-Mediated Immunity Due to IL-12Rβ1 Deficiency in Iranian Patients with Mendelian Susceptibility to Mycobacterial Disease.

A new interesting article has been published in J Clin Immunol. 2018 Sep 25. doi: 10.1007/s10875-018-0548-1. and titled:

Impaired IL-12- and IL-23-Mediated Immunity Due to IL-12Rβ1 Deficiency in Iranian Patients with Mendelian Susceptibility to Mycobacterial Disease.

Authors of this article are:
Nekooie-Marnany N Deswarte C Ostadi V Bagherpour B Taleby E Ganjalikhani-Hakemi M Le Voyer T Rahimi H Rosain J Pourmoghadas Z Sheikhbahaei S Khoshnevisan R Petersheim D Kotlarz D Klein C Boisson-Dupuis S Casanova JL0 Bustamante J Sherkat R.

A summary of the article is shown below:
PURPOSE: Inborn errors of IFN-γ-mediated immunity underlie Mendelian Susceptibility to Mycobacterial Disease (MSMD), which is characterized by an increased susceptibility to severe and recurrent infections caused by weakly virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines and environmental, nontuberculous mycobacteria (NTM).METHODS: In this study, we investigated four patients from four unrelated consanguineous families from Isfahan, Iran, with disseminated BCG disease. We evaluated the patients’ whole blood cell response to IL-12 and IFN-γ, IL-12Rβ1 expression on T cell blasts, and sequenced candidate genes.RESULTS: We report four patients from Isfahan, Iran, ranging from 3 months to 26 years old, with impaired IL-12 signaling. All patients suffered from BCG disease. One of them presented mycobacterial osteomyelitis. By Sanger sequencing, we identified three different types of homozygous mutations in IL12RB1. Expression of IL-12Rβ1 was completely abolished in the four patients with IL12RB1 mutations.CONCLUSIONS: IL-12Rβ1 deficiency was found in the four MSMD Iranian families tested. It is the first report of an Iranian case with S321* mutant IL-12Rβ1 protein. Mycobacterial osteomyelitis is another type of location of BCG infection in an IL-12Rβ1-deficient patient, notified for the first time in this study.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: (BCG)-osis;Bacillus Calmette–Guérin vaccination;IL-12;Mendelian susceptibility to mycobacterial disease;interferon.

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