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Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection.

A new interesting article has been published in Adv Mater. 2018 Sep 25:e1805018. doi: 10.1002/adma.201805018. and titled:

Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection.

Authors of this article are:
Wu J Zheng Z Chong Y Li X Pu L Tang Q Yang L Wang X Wang F Liang G.

A summary of the article is shown below:
Transplant rejection is the key problem in organ transplantation and, in clinic, immunosuppressive agents such as tacrolimus are directly administered to the recipients after surgery for T-cell inhibition. However, direct administration of tacrolimus may bring severe side effects to the recipients. Herein, by rational design of two hydrogelators NapPhePheGluTyrOH (1) and Nap d-Phe dPheGluTyrOH (2), a facile method of immune responsive release of tacrolimus is developed from their hydrogels to overcome organ transplantation rejection. Upon incubation with protein tyrosine kinase, which is activated in T cells after organ transplantation, the tacrolimus-encapsulating Gel 1 or Gel 2 is disassembled to release tacrolimus. Cell experiments show that both Gel 1 and Gel 2 have better inhibition effect on the activated T cells than free drug tacrolimus. Liver transplantation experiments indicate that, after 7 days of treatment of same dose tacrolimus, the recipient rats in the Gel 2 group show significantly extended median survival time of 22 days while the recipients treated with conventional tacrolimus medication have a median survival time of 13 days. It is expected herein that this “smart” facile method of immune responsive release of tacrolimus can be applied to overcome organ transplantation rejection in clinic in the near future.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: hydrogels;immune responsive release;organ transplant rejection;protein tyrosine kinase;tacrolimus.

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