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Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis.

A new interesting article has been published in Neurol Sci. 2018 Sep 25. doi: 10.1007/s10072-018-3582-0. and titled:

Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis.

Authors of this article are:
Baldin E Riise T Mattarozzi K Gajofatto A Granella F Leone M Lugaresi A Malagù S Motti L0 Neri W Pesci I Santangelo M Scandellari C Tola MR Vignatelli L Zenesini C D’Alessandro R; G.E.Ro.N.I.Mu.S. study group.

A summary of the article is shown below:
BACKGROUND AND OBJECTIVES: A few studies have found that low scores on self-rated health and quality of life measures are associated with following worsening disability in multiple sclerosis (MS). We wanted to estimate the association between self-rated quality of life scores among patients with clinically isolated syndrome (CIS) and the risk of subsequent conversion to definite MS.METHODS: One hundred sixty-two patients from the GERONIMUS cohort with a symptom or sign suggestive of MS and without a definite diagnosis of MS at the time of inclusion were asked to evaluate their health-related quality of life according to MSQoL-54 scale. They were clinically assessed and mood and depression scales were applied. The association between the scores of these scales and the risk of converting to definite MS during a 5-year follow-up was estimated using the Cox- proportional hazard regression model.RESULTS: Quality of life at examination was significantly lower compared to those of an age- and sex-adjusted general Italian population. During the follow-up, 116 patients (72%) converted to definite MS. No significant predictive effects were found for the summary scales of MSQol-54 or other scales. The estimates did not change after adjusting for age, sex, BMI, education, MRI findings, Expanded Disability Status Scale (EDSS) score, and treatment at time of examination.CONCLUSION: Persons with CIS in this cohort reported reduced self-rated quality of life compared to the general population, but variation in these scores was not associated with subsequent conversion from CIS to clinical definite MS.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Clinically isolated syndrome (CIS);Multiple sclerosis;Prognostic factors;Prospective study;Quality of life;Self-rated health.

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