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Evaluating the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis.

A new interesting article has been published in Curr Rheumatol Rev. 2018 Sep 25. doi: 10.2174/1573403X14666180926100811. and titled:

Evaluating the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis.

Authors of this article are:
Hashemi G Mirjalili M Basiri Z Tahamoli-Roudsari A Kheiripour N Shahdoust M Ranjbar A Mehrpooya M Ataei S.

A summary of the article is shown below:
BACKGROUND: Rheumatoid arthritis (RA) is a common inflammatory disease of the joints. Due to importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties such as N-acetyl cysteine(NAC), can be effective as adjunctive therapy in patients with RA.AIMS: The aim of this study has been to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA.METHOD: Beside standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks. Serum levels of total oxidant status (TOS), total antioxidant capacity (TAC), nitric oxide (NO), total thiol groups (TTG), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured at baseline and at the end of study.RESULTS: After 12 weeks treatment, results showed that in the NAC group, the serum level of MDA, NO, IL-6, TNF-α, ESR and CRP was significantly lower than that baseline. Also, serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group as compared to the placebo group at the end of study.CONCLUSION: According to the results of this study, oral NAC can significantly reduce the several oxidative stress factors and inflammatory cytokines. These results need to be confirmed in larger studies with considering clinical outcomes of RA patients.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Antioxidants.;Inflammatory cytokines;N-acetylcysteine;Nitrosative stress;Oxidative stress;Rhuematoid Arthritis.

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