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[Epidemiological investigation of hepatitis E virus infection in Tibetan swine population].

A new interesting article has been published in Sheng Wu Gong Cheng Xue Bao. 2018 Sep 25;34(9):1453-1459. doi: 10.13345/j.cjb.180189. English Abstract and titled:

[Epidemiological investigation of hepatitis E virus infection in Tibetan swine population].

Authors of this article are:
Gongga Wang Y; Yixicuomu; Qiongda; Suolangsizhu.

A summary of the article is shown below:
in English, Chinese戊型肝炎病毒 (Hepatitis E Virus,HEV) 感染是一个重要的全球公共卫生问题,而猪被认为是HEV 的天然宿主。HEV 可以跨种间传播,且已经证实生吃感染的猪肉会导致人感染。在中国西藏许多地区仍然有生吃猪肉、猪肝等的习惯,且不同种家畜混合饲养,极易造成HEV 感染和传播。然而中国西藏地区猪HEV 流行情况报道甚少。文中对中国西藏5 个地区市 (拉萨、日喀则、山南、那曲和昌都) 猪血清进行HEV Immunoglobulin-M(IgM) 和IgG 抗体检测,并通过逆转录巢氏PCR (RT-nPCR) 进行HEV RNA 检测和定量RT-PCR (qRT-PCR) 进行病毒拷贝计算,首次报道了藏猪血清HEV RNA 阳性率。结果显示,在西藏猪中HEV 有较高的流行趋势。猪血清HEV IgM 抗体阳性率高达7.6% (26/340),HEV IgG 抗体阳性率为1.8% (6/340),HEV RNA 阳性率高达7.6%(26/340),血清中病毒拷贝高达1.7×10⁷ copies/mL,而且5 个地区有不同的流行趋势。结果表明西藏猪HEV 感染情况严重。有关部门应加强管理,以避免人与动物之间的交叉感染和暴发。.Hepatitis E virus (HEV) infection is a main global public health issue. HEV can be zoonotically transmitted across species, and swine is recognized as a major reservoir of HEV. However, information is lacking on the prevalence of HEV infection in Tibet of China, where raw pork and mixed farming of different species of domestic animals are consumed traditionally. In this study, swine serum was collected for HEV IgM and IgG antibodies test from five regions in Tibet of China. Meanwhile, HEV RNA was detected in swine sera. HEV has a high prevalence trend in Tibetan swine. Swine serum anti-HEV IgM antibody positive rate was as high as 7.6%, the positive rate of anti-HEV IgG antibody was 1.8%, the positive rate of HEV RNA also was 7.6%, the virus titers in serum was above 1.7×10⁷ copies/mL, and there were different epidemic trends in five regions. In conclusion, antibody detection and RNA detection showed that swine in Tibet had a higher incidence of HEV infection. HEV infection in Tibetan swine is more serious and management should be strengthened to avoid cross-infection between humans and animals and outbreaks in Tibet.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Hepatitis E virus;Tibet (China);swine.

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