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[Efficacy enhancement of a Baculovirus-vectored Newcastle Disease Virus F protein vaccine by chicken GM-CSF and IL-2].

A new interesting article has been published in Sheng Wu Gong Cheng Xue Bao. 2018 Sep 25;34(9):1442-1452. doi: 10.13345/j.cjb.170505. English Abstract and titled:

[Efficacy enhancement of a Baculovirus-vectored Newcastle Disease Virus F protein vaccine by chicken GM-CSF and IL-2].

Authors of this article are:
Yu H Gao D Shen Y Liu Y Ping W Ge J.

A summary of the article is shown below:
in English, Chinese为比较鸡粒细胞-巨噬细胞集落刺激因子 (Granulocyte macrophage colony stimulating factor,GM-CSF)及鸡白细胞介素2 (Interleukin 2,IL-2) 对杆状病毒疫苗的免疫增强效果,通过基因工程手段构建重组杆状病毒疫苗 (Recombinant Baculovirus,BV) rBV-LMI-F,并联合GM-CSF 及IL-2 进行鸡体免疫。对中和抗体水平及细胞因子含量比较GM-CSF 和IL-2 的免疫增强效果进行对比。结果显示,在第一次免疫28 d 或42 d 后,GM-CSF联合免疫组可诱导鸡体产生更高的抗体和细胞因子水平 (P<0.01)。表明鸡GM-CSF 能更有效地刺激机体产生较强的抗体和细胞因子反应,提高重组杆状病毒疫苗的免疫效果。.To compare with the effects of the GM-CSF and IL-2 used as adjuvants in the baculovirus vaccine, we used genetic engineering to construct the recombinant baculovirus rBV-LMI-F and with GM-CSF and IL-2 to immunized chickens. Then, we compared the concentration of the neutralizing antibody and cytokines to determine the immunostimulatory effects of GM-CSF and IL-2. GM-CSF induced higher levels of antibodies and cytokines in chickens at 28 d and 42 d post-vaccination. In conclusion, GM-CSF could elicit higher serum antibody and cytokines responses and improved the effects of Baculovirus vaccine.
Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: GM-CSF;IL-2;Newcastle disease;co-immunization;immune effect.

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