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Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction.

A new interesting article has been published in Neurol Sci. 2018 Sep 25. doi: 10.1007/s10072-018-3569-x. and titled:

Does fatigue in Parkinson’s disease correlate with autonomic nervous system dysfunction.

Authors of this article are:
Olivola E Brusa L Rocchi C Schillaci O Liguori C Cerroni R Pierantozzi M Chiaravalloti A Stefani A Stocchi F.

A summary of the article is shown below:
BACKGROUND: Despite its negative impact on quality of life, fatigue in Parkinson’s disease (PD) remains an under-recognized issue and the underlying pathology is undetermined.OBJECTIVE: To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients.METHODS: In a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests.RESULTS: PFS-16 score correlated with disease duration (R = 0.57, p = 0.002). Fatigue showed a clear correlation with deep breathing test (R = - 0.53, p = 0.004) but not with the MIBG H/M ratios.CONCLUSIONS: Our data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Autonomic nervous system;Fatigue;Myocardial scintigraphy;Parkinson’s disease.

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