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Comparison of ethanol tolerance between potential cyanobacterial production hosts.

A new interesting article has been published in J Biotechnol. 2018 Oct 10;283:140-145. doi: 10.1016/j.jbiotec.2018.07.034. Epub 2018 Jul 27. and titled:

Comparison of ethanol tolerance between potential cyanobacterial production hosts.

Authors of this article are:
Kämäräinen J1, Nylund M1, Aro EM1, Kallio P2.

A summary of the article is shown below:
Cyanobacteria are photosynthetic prokaryotes that have been extensively studied as potential autotrophic biotechnological hosts for the production of different carbon-based end-products directly from atmospheric CO2. While commercially competitive applications do not yet exist, the production of ethanol in cyanobacteria is the most mature technology, endorsed by relatively high production yields and established status of ethanol in the global biofuel market. Within this concept, the aim here was to systematically compare ethanol tolerance of different commonly used cyanobacterial strains and substrains, in order to assess their relative potential for biotechnological production platforms. The comparison revealed clear strain-specific differences in ethanol toxicity, with growth inhibition GI50 values ranging between 3 g L-1 (0.4% V/V) and 28 g L-1 (3.5% V/V). The most tolerant wild-type strains were Synechocystis sp. PCC 6803 (substrain A) and Synechococcus sp. PCC 7002, which did not show any apparent effect in growth below ethanol concentrations 9.2 g L-1 (1.2% V/V). In comparison to typical biotechnological yeast strains used for ethanol fermentation, these values are clearly lower but still around the same order of magnitude. The results also underlined the challenges in direct number-based comparison between cyanobacterial strains and culture conditions due to inconsistencies in respect to chlorophyll content, cell morphology and optical properties.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Cyanobacteria;Ethanol tolerance;Photoautotrophic biotechnological host;Sensitivity to ethanol.

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