Science News

Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones.

A new interesting article has been published in Org Biomol Chem. 2018 Oct 10;16(39):7214-7222. doi: 10.1039/c8ob01970c. and titled:

Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones.

Authors of this article are:
Xu H Sha F Li Q Wu XY.

A summary of the article is shown below:
An organocatalytic enantioselective Tamura cycloaddition between homophthalic anhydrides and 2-arylidene-1,3-indanediones has been developed. With 2 mol% of commercially available (DHQD)2PYR, a wide range of enantioenriched spiro-1,3-indanedione derivatives were obtained in good-to-excellent yields (68-98%), excellent diastereoselectivities (99 : 1 dr) and moderate-to-excellent enantioselectivities (up to 95% ee).

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: n/a.

Categories: Science News