Associations between PET Amyloid Pathology and DTI Brain Connectivity in Preclinical Alzheimer’s Disease.
Authors of this article are:
Hwang SJ Adluru N Kim WH Johnson S Bendlin BB Singh V.
A summary of the article is shown below:
Characterizing Alzheimer’s disease (AD) at preclinical stages is crucial for initiating early treatment strategies. It is widely accepted that amyloid accumulation is a primary pathological event in AD. Also, loss of connectivity between brain regions is suspected of contributing to cognitive decline, but studies which test these associations using either local (i.e., individual edges) or global (i.e., modularity) connectivity measures may be limited. In the current study, we utilized data acquired in 139 cognitively unimpaired participants. Sixteen gray matter regions known to be affected by AD were selected for analysis. For each of the 16 regions, the effect of amyloid burden, measured using Pittsburgh Compound B (PiB) PET, on each of the 1,761 brain network connections derived from diffusion tensor imaging (DTI) connecting 162 gray matter regions was investigated. Applying our unique multi-resolution statistical analysis called the Wavelet Connectivity Signature (WaCS), this study demonstrates the relationship between amyloid burden and structural brain connectivity as assessed with DTI. Our statistical analysis using WaCS shows that in 15 / 16 gray matter regions, statistically significant relationships between amyloid burden in those regions and structural connectivity networks were observed. After applying multiple testing correction, 10 unique structural brain connections were found to be significantly associated with amyloid accumulation. For 7 of those 10 network connections, the decrease in their network connection strength indexed by fractional anisotropy was in turn associated with lower cognitive function providing evidence that AD-related structural connectivity loss is a correlate of cognitive decline.
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This article is a good source of information and a good way to become familiar with topics such as: Alzheimer’s Disease;Brain connectivity;Diffusion tensor imaging (DTI);Positron emission tomography (PET).
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