The Effects of Repeated Exposure to Zinc- and Copper-Containing Welding Fumes on Healthy Volunteers.
Authors of this article are:
Krabbe J Beilmann V Gerhards B Markert A Thomas K Kraus T Brand P.
A summary of the article is shown below:
OBJECTIVE: Recently, the proinflammatory effects of welding fumes containing zinc and copper have been demonstrated. In the present study, it was investigated if the inflammation persists under repeated exposure.METHODS: 15 healthy male subjects were exposed to 6 hours of exposure with zinc- and copper-containing welding fumes on four consecutive days under controlled conditions.RESULTS: Inflammatory marker serum levels showed significant increases compared to baseline after either 6 or 24 hours after the first exposure and stayed elevated for all following exposures. In nasal secret samples only C-reactive protein levels were increased compared to baseline.CONCLUSIONS: The demonstrated a persistent increase of systemic inflammatory markers indicates an elevated risk for welders chronically exposed to zinc- and copper-containing welding fumes. Topical inflammation of the upper airways did not occur.
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