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Structural studies of calcium channel blockers used in the treatment of hypertension – 1 H and 13 C NMR characteristics of nifedipine analogues.

A new interesting article has been published in Magn Reson Chem. 2018 Sep 26. doi: 10.1002/mrc.4797. Letter and titled:

Structural studies of calcium channel blockers used in the treatment of hypertension – 1 H and 13 C NMR characteristics of nifedipine analogues.

Authors of this article are:
Szeleszczuk Ł Zielińska-Pisklak M Pisklak DM.

A summary of the article is shown below:
The 1 H and 13 C NMR spectroscopy in solution was applied to characterize a series of active pharmaceutical ingredients (API) belonging to the class of calcium channel blockers, a group of drug substances extremely sensitive to UV radiation: nifedipine (1), nitrendipine (2), nisoldipine (3), nimodipine (4), nilvadipine (5), felodipine (6) isradipine (7) nicardipine (8) and amlodipine besylate (9). Two-dimensional NMR experiments (COSY, HSQC, HMBC) allowed the unequivocal assignments of peaks in the 1 H and 13 C spectra in solution and in some cases enabled editing of incorrect assignments appearing in the scientific literature. Various nifedipine derivatives can be easily distinguished based on their 13 C chemical shifts. 1 H and 13 C chemical shifts analysis provides fast identification of the drug substance and ensures its stability in the commercial dosage forms from different sources.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: calcium channel blockers;chemical shifts assignments;dihydropyridines;nifedipine analogues;solution NMR spectroscopy;stability of drug substances.

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