Structural studies of calcium channel blockers used in the treatment of hypertension – 1 H and 13 C NMR characteristics of nifedipine analogues.
Authors of this article are:
Szeleszczuk Ł Zielińska-Pisklak M Pisklak DM.
A summary of the article is shown below:
The 1 H and 13 C NMR spectroscopy in solution was applied to characterize a series of active pharmaceutical ingredients (API) belonging to the class of calcium channel blockers, a group of drug substances extremely sensitive to UV radiation: nifedipine (1), nitrendipine (2), nisoldipine (3), nimodipine (4), nilvadipine (5), felodipine (6) isradipine (7) nicardipine (8) and amlodipine besylate (9). Two-dimensional NMR experiments (COSY, HSQC, HMBC) allowed the unequivocal assignments of peaks in the 1 H and 13 C spectra in solution and in some cases enabled editing of incorrect assignments appearing in the scientific literature. Various nifedipine derivatives can be easily distinguished based on their 13 C chemical shifts. 1 H and 13 C chemical shifts analysis provides fast identification of the drug substance and ensures its stability in the commercial dosage forms from different sources.
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