Science News

Ruthenium(ii)-catalyzed synthesis of indazolone-fused cinnolines via C-H coupling with diazo compounds.

A new interesting article has been published in Org Biomol Chem. 2018 Oct 10;16(39):7236-7244. doi: 10.1039/c8ob02071j. and titled:

Ruthenium(ii)-catalyzed synthesis of indazolone-fused cinnolines via C-H coupling with diazo compounds.

Authors of this article are:
Su L Yu Z Ren P Luo Z Hou W Xu H.

A summary of the article is shown below:
A robust, efficient and scalable method for the synthesis of 12H-indazolo[2,1-a]cinnolin-12-ones was developed. Significantly, a less developed cationic complex [Ru(p-cymene)(MeCN)3(SbF6)2] was found to be effective for this transformation. In this reaction, a tandem pathway of C-H ruthenation, Ru(ii)-carbene formation, migratory insertion and condensation was involved. The results of a primary mechanistic study suggested that the C-H activation process might follow an electrophilic-type metalation/deprotonation mechanism.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: n/a.

Categories: Science News