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Lipid metabolism and intracellular bacterial virulence: key to next-generation therapeutics.

A new interesting article has been published in Future Microbiol. 2018 Sep;13:1301-1328. doi: 10.2217/fmb-2018-0013. Epub 2018 Sep 26. Research Support, Non-U.S. Gov’t and titled:

Lipid metabolism and intracellular bacterial virulence: key to next-generation therapeutics.

Authors of this article are:
Rameshwaram NR Singh P Ghosh S Mukhopadhyay S.

A summary of the article is shown below:
Lipid metabolism is thought to play a key role in the pathogenicity of several intracellular bacteria. Bacterial lipolytic enzymes hydrolyze lipids from the host cell to release free fatty acids which are used as an energy source and building blocks for the synthesis of cell envelope and also to modulate host immune responses. In this review, we discussed the role of lipid metabolism and lipolytic enzymes in the life cycle and virulence of Mycobacterium tuberculosis and other intracellular bacteria. The lipolytic enzymes appear to be potential candidates for developing novel therapeutics by targeting lipid metabolism for controlling M. tuberculosis and other intracellular pathogenic bacteria. [Formula: see text].

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Mycobacterium tuberculosis;host lipids;intracellular bacteria;lipid rafts;lipolytic enzymes;pathogenicity;therapeutic targets;virulence.

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