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Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance.

A new interesting article has been published in Drug Dev Res. 2018 Sep 26. doi: 10.1002/ddr.21456. and titled:

Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance.

Authors of this article are:
Almeida JR Palacios ALV Patiño RSP Mendes B Teixeira CAS Gomes P da Silva SL.

A summary of the article is shown below:
Hit, Lead & Candidate Discovery The emergence of antibiotic resistance drives an essential race against time to reveal new molecular structures capable of addressing this alarming global health problem. Snake venoms are natural catalogs of multifunctional toxins and privileged frameworks, which serve as potential templates for the inspiration of novel treatment strategies for combating antibiotic resistant bacteria. Phospholipases A2 (PLA2 s) are one of the main classes of antibacterial biomolecules, with recognized therapeutic value, found in these valuable secretions. Recently, a number of biomimetic oligopeptides based on small fragments of primary structure from PLA2 toxins has emerged as a meaningful opportunity to overcome multidrug-resistant clinical isolates. Thus, this review will highlight the biochemical and structural properties of antibacterial PLA2 s and peptides thereof, as well as their possible molecular mechanisms of action and key roles in development of effective therapeutic strategies. Chemical strategies possibly useful to convert antibacterial peptides from PLA2 s to efficient drugs will be equally addressed.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: antibacterial peptides;antibiotic-resistant bacteria;peptidomimetics;phospholipase A2;snake venom.

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