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Enantioselective Access to 1H-Isoindoles with Quaternary Stereogenic Centers by Palladium(0)-Catalyzed C-H Functionalization. – PubMed – NCBI

A new interesting article has been published in Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13644-13647. doi: 10.1002/anie.201809173. Epub 2018 Sep 19. and titled:

Enantioselective Access to 1H-Isoindoles with Quaternary Stereogenic Centers by Palladium(0)-Catalyzed C-H Functionalization. – PubMed – NCBI

Authors of this article are:
Grosheva D1, Cramer N1.

A summary of the article is shown below:
A catalytic enantioselective method for the synthesis of chiral 1H-isoindoles bearing quaternary stereogenic centers is reported. Powered by readily accessible phosphordiamidite ligands, the presented palladium(0)-catalyzed C-H functionalization uses trifluoroacetimidoyl chlorides as electrophilic components. It delivers previously inaccessible perfluoroalkylated 1H-isoindoles in high yields and enantioselectivities. The subsequent diastereoselective addition of nucleophiles provides access to densely substituted and sterically hindered isoindolines.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: C−H activation;asymmetric catalysis;fluorine;heterocycles;palladium.

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