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Design, synthesis, and applications of DNA-macrocyclic host conjugates.

A new interesting article has been published in Chem Commun (Camb). 2018 Sep 26. doi: 10.1039/c8cc06716c. and titled:

Design, synthesis, and applications of DNA-macrocyclic host conjugates.

Authors of this article are:
Zhou X Pathak P Jayawickramarajah J.

A summary of the article is shown below:
With this Feature Article we review, for the first time, the development of DNA-host conjugates-a nascent yet rapidly growing research focus within the ambit of DNA supramolecular chemistry. Synthetic hosts (such as cyclodextrins, cucurbiturils, and calixarenes) are well-suited to be partnered with DNA, since DNA assembly and host-guest binding both thrive in aqueous media, are largely orthogonal, and exhibit controllable and input-responsive properties. The covalent braiding of these two supramolecular synthons thus leads to advanced self-assemblies and nanostructures with exciting function that range from drug delivery agents to input-triggered switches. The latter class of DNA-host conjugates have been demonstrated to precisely control protein activity, and have also been used as modulable catalysts and versatile biosensors.

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