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Brain imaging can predict neurodevelopmental outcome of Group B streptococcal meningitis in neonates.

A new interesting article has been published in Acta Paediatr. 2018 Sep 26. doi: 10.1111/apa.14593. and titled:

Brain imaging can predict neurodevelopmental outcome of Group B streptococcal meningitis in neonates.

Authors of this article are:
Martis JMS Bok LA Halbertsma FJJ van Straaten HLM de Vries LS Groenendaal F.

A summary of the article is shown below:
AIM: The association between cranial ultrasound (CUS) or magnetic resonance imaging (MRI) lesions and neonatal Group B streptococcal (GBS) meningitis outcome has not been studied in detail.METHODS: This retrospective study, assessed CUS, cranial MRI, and neurodevelopmental outcome in 50 neonates with GBS meningitis admitted to three neonatal intensive care units in The Netherlands between 1992 and 2014. Death, cognitive and motor outcome below -1SD were considered as adverse outcomes.RESULTS: CUS was available in all and MRIs in 31 infants (62%) with 28 CUS (56%) and 27 MRIs (87%) being abnormal. MRI lesions were multifocal (n =10, 37%), bilateral (n=22; 82%) and extensive (n=11; 41%). A total of 10 died in the neonatal period. Median age at assessment was 24 months. Among survivors, abnormal cognitive and motor outcome was seen in 23 and 20 patients respectively. Abnormal CUS (odds ratio (OR) 5.3, p = 0.017), extensive bilateral deep grey lesions (OR 6.7, p = 0.035) and white matter lesions (OR 14.0, p = 0.039) correlated with abnormal motor outcome. Extensive bilateral deep grey matter lesions correlated with abnormal cognitive outcome (OR 8.1, p = 0.029).CONCLUSION: Abnormal CUS and the most severely affected MRIs were associated with poor neurodevelopmental outcome in neonatal GBS meningitis. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

Check out the article’s website on Pubmed for more information:



This article is a good source of information and a good way to become familiar with topics such as: Cranial ultrasound;Group B streptococcus;magnetic resonance imaging;neurodevelopmental outcome;newborn infant.

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