A model of oxygen transport in the rat renal medulla.
Authors of this article are:
Lee CJ Gardiner BS Evans RG Smith DW.
A summary of the article is shown below:
The renal medulla is prone to hypoxia. Medullary hypoxia is postulated to be a leading cause of acute kidney injury, so there is considerable interest in predicting the oxygen tension in the medulla. Therefore we have developed a computational model for blood and oxygen transport within a physiologically normal rat renal medulla, using a multi-level modeling approach. For the top-level model we use the theory of porous media and advection-dispersion transport through a realistic three-dimensional (3D) representation of the medulla’s gross anatomy, to describe blood flow and oxygen transport throughout the renal medulla. For the lower-level models, we employ two-dimensional (2D) reaction-diffusion models describing the distribution of oxygen through tissue surrounding the vasculature. Steady-state model predictions at the two levels are satisfied simultaneously, through iteration between the levels. The computational model was validated by simulating eight sets of experimental data regarding renal oxygenation in rats (using four sets of control groups and four sets of treatment groups, described in four independent publications). Predicted medullary tissue oxygen tension (PtO2) or microvascular oxygen tension (µPO2) for control groups and for treatment groups that underwent moderate perturbation in hemodynamic and renal functions, is within ± 2 standard error of mean (SEM) values observed experimentally. Diffusive shunting between descending and ascending vasa recta is predicted to be only 3% of the oxygen delivered. The validation tests confirm that the computational model is robust and capable of capturing the behavior of renal medullary oxygenation in both normal and early stage pathologic states in the rat.
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This article is a good source of information and a good way to become familiar with topics such as: Acute Kidney Injury;Computational Model;Hypoxia;Oxygen Tension;Renal Oxygenation.
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