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β-Glucuronidase and its Relationship with Clinical Parameters and Biomarkers of Pesticide Exposure.

A new interesting article has been published in J Occup Environ Med. 2018 Sep 25. doi: 10.1097/JOM.0000000000001460. and titled:

β-Glucuronidase and its Relationship with Clinical Parameters and Biomarkers of Pesticide Exposure.

Authors of this article are:
Arias MAR Moreno JFH Medina-Díaz IM Hernández YYB Arias CAG Rojas E.

A summary of the article is shown below:
OBJECTIVE: This study determined β-glucuronidase activity and its relationship with clinical, biochemical and pesticide-exposure biomarkers in workers occupationally exposed mainly to OP insecticides.METHODS: A cross-sectional study was conducted in pesticide applicators. Three study groups were established: reference group; moderate-exposure group, and high-exposure group. Blood samples were obtained to determine the activity of β-glucuronidase. Clinical analysis was conducted in a certified laboratory.RESULTS: The activity of β-glucuronidase was associated with clinical variables such as glucose, cholesterol, triglycerides, LDL, VLDL, and HDL, atherogenic index, transaminases, and BuChE activity, but not with AChE activity. The activity of this enzyme exhibited a significant increase in the group of moderate exposure to pesticides but not in the group of high exposure.CONCLUSION: β-Glucuronidase activity is a sensitive biomarker under certain scenarios of OP exposure.

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