Pharmaceutics Calculations Practice Set #12 with Answers

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**Question 1**

Calculate the NaCl equivalent of 1% solution of pilocarpine nitrate (MW = 271; i = 1.8).

A. 0.18

B. 0.22

C. 0.27

D. 0.30

**Question 2**

How many grams of potassium nitrate could be used to make the following prescription isotonic?

Rx) Sol. Silver Nitrate 60 mL

1:500 w/v

Make isoton. Sol.

Sig. For eye use

S. N. E = 0.33

P. N. E = 0.58

A. 0.5

B. 0.86

C. 0.54

D. 0.6

**Question 3**

How many grams of sodium chloride should be used in compounding the following prescription?

Pilocarpine Nitrate 0.3 g (E = 0.23)

Sodium Chloride q.s.

Purified Water ad 30 mL

Make isotonic solution

Sig. For the eye

A. 0.4

B. 0.15

C. 0.2

D. 0.35

**Question 4**

Determine the volume of purified water and 0.9% w/v NaCl solution needed to prepare 20 mL of a 1% w/v solution of hydromorphone HCl (E=0.22)

A. 4.9 & 15.1

B. 0 & 20

C. 10 & 10

D. 15 & 5

**Question 5**

Using the E values, calculate the number of mL of water required to make an isotonic solution from 0.3 g of each of the following:

A. 11

B. 8

C. 5

D. 7.6

B 1. chlorobutanol [E = 0.24]

D 2. ephedrine sulfate [E=0.23]

A 3. silver nitrate [E=0.33]

C 4. zinc sulfate [E=0.15]

**Question 6**

Calculate the E values for each of the following, given that the number of mL of water shown will produce an isotonic solution from 0.3 g of drug.

A. 0.08

B. 0.22

C. 0.16

D. 0.2

C 1. Ethylmorphine HCl, 5.3 mL water

D 2. Holocaine HCl, 6.7 mL water

B 3. Procainamide HCl, 7.3 mL water

A 4. Viomycin sulfate, 2.7 mL water

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