Pharmaceutics Calculations Practice Set #11 with Answers

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**Question 1**

Phenylephrine HCl 1%

Purified water qs 30 mL

Make isotonic solution

Given: ΔTf,1% (NaCl) = 0.58

ΔTf,1% (P.H.) = 0.18

How many grams of NaCl should be added?

A. 0.586

B. 0.310

C. 0.176

D. 0.093

**Question 2**

Pilocarpine nitrate 1%

Purified water qs 50 mL

Make solution isotonic

Given: ΔTf,1% (NaCl) = 0.58

ΔTf,1% (P.N.) = 0.14

Calculate the amount of NaCl in mg needed to make the solution isotonic.

A. 328

B. 655

C. 241

D. 121

**Question 3**

How many milligrams each of NaCl and dibucaine HCl are required to prepare 30 mL of a 1% solution of dibucaine HCl isotonic with tears?

A. 45 & 23

B. 76 & 30

C. 0.228 & 0.3

D. 228 & 300

**Question 4**

Procaine HCl (MW = 273) is a 2 ion electrolyte, dissociating 80%

Calculate the dissociation factor (i) NaCl equivalent (E)

A. 1.8 & 0.21

B. 2.4 & 0.29

C. 2.4 & 0.32

D. 1.8 & 0.29

**Question 5**

Calculate the NaCl equivalent of 1% zinc chloride solution (MW = 136; i = 2.6).

A. 0.21

B. 0.62

C. 0.44

D. 0.32

**Question 6**

Calculate the sodium chloride equivalent for fluorescein sodium, which dissociates into three ions and has a molecular weight of 376.

A. 0.45

B. 0.41

C. 0.32

D. 0.22

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