Modified versions of the common, heavily used, antibiotic vancomycin have been synthesized. These modified antibiotics contain structural and functional changes that allow them not only to bypass bacterial resistance mechanisms that develop over time, they also provide them with new ways to fight bacterial infections. The new antibiotics add to the existent mechanisms of glycopeptide inhibition during cell wall synthesis by inducing cell wall permeability. These newly designed antibiotics bring the hope of fighting bacterial infections with more effective and more durable antibiotics. The research describing these findings has been published in the journal PNAS by lead author Akinori Okano et al.